The Effect of 12 Week Combined Exercise Training on Fibrin De Dimer and Interlukin-6 Levels in Female Multiple Sclerosis Patients
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Authors
1کارشناسی ارشد
2Department of Sport Sciences, Shahrekord University, Shahrekord, Iran.
3Department of Sport Sciences, Shahrekord University, Shahrekord, Iran
Abstract
Introduction: A neurological disease with a variety of signs and symptoms. Multiple sclerosis (MS) is the most common chronic inflammatory disorder of the central nervous system (CNS) in young adult. D-dimer influence inflammatory and acute-phase responses by promoting neutrophil and monocyte activation, inducing the release of IL-6. The aim of the study was to examine the effect of combined exercise training on serum Fibrin De Dimer (FDD) and interlukin-6 in female multiple sclerosis patients with different levels of disability.
Methodology: 96 female MS patients subjects were selected and divided into three groups based on the physical disability scale scores (EDSS); i.e. (less than 4.5, 5 - 6.5, and higher than 6.5). Afterwards each group was divided randomly into an experimental and a control group. The first EDSS less than 4.5 group, n= 44, second group (EDSS 5 - 6.5), n=26, and third group EDSS 6.5 and above, n=26. In addition, they were divided into 6 experimental and control groups. Blood sample were taken 24 before and 48 hours after exercise program for measurement of fibrin D-dimer, IL-6. Participants performed 12 weeks combined strength, endurance, Pilates and PNF training, three sessions per week and 45 to 60 minute for each session. Dependent and Independent t-test were used to compare between and within mean between groups, respectively.
Results: The results showed significant decrease in fibrin de dimer (p= 0.001) and interlukine-6 (p= 0.001) in low disability group and interlukine-6 (p=0.004) in sever disability group. The result of this study showed that 12 week of combined exercise lead to reduce fibrin D-dimer and IL-6 in low disability group but no significant change was observed in moderate and high disability groups.
Discussion: It appears that performing combined exercise training result in decrease in fibrin de-dimer, interlukine-6 and inflammation of low disability MS patients. Thus, it is recommended use these exercises as a complementary therapy alongside drug treatments for M.S patients.
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