The effect of high intensity endurance training on plasma levels of Amyloid beta 42 (Aβ42) and total antioxidant capacity (TAC) in type 2 diabetic women
Poster Presentation XML
Paper ID : 1159-11THCONF
1Professor Assistant in Exercise Physiology
2Department of Physical Education and Sport Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
Introduction: Type 2 diabetes is known as a risk factor for dementia and Alzheimer's disease and physical activity and exercise are one of the strategies for the prevention and treatment of diabetes and Alzheimer's disease. Therefore, the purpose of present study was to evaluate the effect of eight weeks high intensity endurance training on plasma levels of amyloid β 42 (Aβ42) and total antioxidant capacity (TAC) in type 2 diabetic women.
Methodology: For this purpose, 16 type 2 diabetic women with 50 to 60 year old, randomly divided into 2 groups include high intensity endurance training and control group. High intensity training group include of 30 min with 80% of HR reserve, 3 session per week and for 8 weeks. Blood samples were taken 24 hours before and 48 hours after last session training. Aβ42 level measured by using an ELISA kit and TAC level measured by chromatography method. Data was analyzed using paired t test and independent t test at significant levels of P<0.05.
Results: The results show that endurance training with high intensity decrease plasma levels of Aβ42in type 2 diabetic women (P=0.011). But endurance training with moderate intensity didn’t has any effect on plasma TAC levels in type 2 diabetes mellitus (P=0.892).
Discussion: These results showed the beneficial effects of high intensity endurance training on Aβ42 levels in diabetes. Based on these results, endurance training trough reducing Aβ42 levels could avoid side effects of diabetes in the nervous system and other organs and recommend as a therapeutic strategy for diabetes.