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Effect of eight-week zinc supplementation and combined exercises on growth hormone and insulin-like levels 1 in middle-aged male patients with colon cancer
Poster Presentation
Paper ID : 1168-11THCONF
Authors
1education department
2دانشجو
3عضو هیات علمی دانشگاه آزاد زنجان
4عضو هیات علمی دانشگاه علوم پزشکی استان زنجان
5Azad University- Zanjan branch
Abstract
Introduction: This study was conducted to evaluate the effect of eight weeks of combined exercise (endurance and resilience) and zinc supplementation on plasma levels of growth hormone and insulin-like growth factor1 in male patients with colon cancer.
Methodology: 40 men with colon cancer (age: 43.6 ± 0.69, weight: 72.77 ± 9.43 and 4.21 BMI) were selected by random sampling and randomly divided into four groups Combined exercises with zinc supplementation, combined exercise, zinc supplementation and control were divided. Subjects in groups one and two, eight weeks, three sessions each week, completed endurance and resistance training exercises. Patients in groups one and three received a total of 15 mg zinc supplement pills for eight weeks a day in two meals per meal. During the experimental period, no control exercises and supplements were performed on the control group. 5 ml of the blood sample of each subject was taken in a 12-hour fasting state one day before the start of the course and one day after completion. Levels of growth hormone and insulin-like growth factor 1 were measured by ECL method. To analyze the data, t-test, two-way covariance and Bonferron's post hoc test were used at the significance level (α≤0.05).
Results: The results of statistical methods and comparison of pre-test and post-test in four groups showed that eight weeks of combined exercises with zinc supplementation led to increased levels of growth hormone and decreased levels of plasma insulin-like growth factor-1 in the subjects (α ≤ 0.05). However, zinc supplementation and exercise training alone did not have a significant effect on plasma levels of growth hormone and plasma insulin-like growth factor-1 alone. Comparison of post-tests of the four groups showed that Zinc supplementation and combined exercise exercises compared to other interventions significantly decreased the level of plasma insulin-like growth factor-1 and significantly increased growth hormone levels (P = 0.003) in these patients.
Discussion: Long-term exercise of combination (endurance and resistance) exercises along with zinc supplementation can affect the plasma levels of growth anabolic hormones and insulin-like growth factor 1 in colon cancer patients and cause changes in the anabolic half-life of the body.
Methodology: 40 men with colon cancer (age: 43.6 ± 0.69, weight: 72.77 ± 9.43 and 4.21 BMI) were selected by random sampling and randomly divided into four groups Combined exercises with zinc supplementation, combined exercise, zinc supplementation and control were divided. Subjects in groups one and two, eight weeks, three sessions each week, completed endurance and resistance training exercises. Patients in groups one and three received a total of 15 mg zinc supplement pills for eight weeks a day in two meals per meal. During the experimental period, no control exercises and supplements were performed on the control group. 5 ml of the blood sample of each subject was taken in a 12-hour fasting state one day before the start of the course and one day after completion. Levels of growth hormone and insulin-like growth factor 1 were measured by ECL method. To analyze the data, t-test, two-way covariance and Bonferron's post hoc test were used at the significance level (α≤0.05).
Results: The results of statistical methods and comparison of pre-test and post-test in four groups showed that eight weeks of combined exercises with zinc supplementation led to increased levels of growth hormone and decreased levels of plasma insulin-like growth factor-1 in the subjects (α ≤ 0.05). However, zinc supplementation and exercise training alone did not have a significant effect on plasma levels of growth hormone and plasma insulin-like growth factor-1 alone. Comparison of post-tests of the four groups showed that Zinc supplementation and combined exercise exercises compared to other interventions significantly decreased the level of plasma insulin-like growth factor-1 and significantly increased growth hormone levels (P = 0.003) in these patients.
Discussion: Long-term exercise of combination (endurance and resistance) exercises along with zinc supplementation can affect the plasma levels of growth anabolic hormones and insulin-like growth factor 1 in colon cancer patients and cause changes in the anabolic half-life of the body.
Keywords
growth hormone; Insulin-like growth factor 1; Combined exercise (endurance and resistance); zinc supplementation; Colon cancer
Subjects