Effects of physical activity with and without garlic supplementation on apoptosis and Risk Factors of cardiovascular risk factors in rats with metabolic syndrome
Oral Presentation XML
Authors
1Faculty of sports sciences, Razi University, Kermanshah, 6714414874, Iran
2Associate Professor of Physical Education at Razi University of Kermanshah
3Drug applied research center, Tabriz University of Medical Sciences, Tabriz, 5165687386, Iran
Abstract
Introduction: Exercise and diet are two lifestyle factors that affect cardiovascular risk factors. The antioxidant properties of garlic extract (GE) supplementation with exercise remains poorly studied on cardiovascular risk factors and apoptosis in people with metabolic syndrome (MetS). The purpose of this study was to investigate the effects of 8 weeks endurance and resistance training with and without garlic extract supplementation and garlic extract supplementation alone on apoptosis and cardiovascular risk factors in rats with metabolic syndrome.
Methodology: This study conducted with a between groups design on 48 rats with metabolic syndrome (aged 12-wk, with a weight range of 331.9±13.7 g) that were randomly divided into 6 groups of 8 each: endurance training (ET), resistance training (RT) garlic extract supplementation (GE), endurance training with garlic extract supplementation (ET+GE), resistance training with garlic extract supplementation (RT+GE) and metabolic syndrome-control (MetS-Con). Endurance and resistance training were performed 3 times per week and consisted of running on the treadmill or a rat climbing ladder with weights fastened to the tail. The supplementation consisted of 500 mg.kg-1.day-1 of garlic extract.
Results: Results showed that BCL2-associated X protein (Bax) and insulin resistance (IR) were significantly lower in all intervention groups compared to the MetS-Con group. And except the RT+GE group, high-sensitivity C-reactive protein (hs-CRP) and glucose were also significantly lower in all groups compared to the MetS-Con group. Moreover, levels of homocysteine (Hcy) were significantly lower in ET, ET+GE, RT+GE groups compared to the MetS-Con group. There were significant differences for the levels of total antioxidant capacity (TAC) between ET, GE, ET+GE groups compared to the MetS-Con group.
Discussion: In conclusion, endurance and resistance training with or without garlic extract supplementation and the supplementation alone could improve antioxidant capacity, inflammation and apoptosis in rats with metabolic syndrome. However, the combination of garlic supplementation and endurance exercise seems to be more helpful than the other interventions in reducing coronary artery disease.
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