Effect of Taxol Consume and Endurance Training on Cyclooxygenase2 and Prostaglandin in the Liver Tissue Mice C57 with Cervical Cancer
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Authors
11. MSc, Department of Exercise Physiology, Islamic Azad University Ayatollah Amoli Branch, Amol, Iran
2Associate Professor, Department of Exercise Physiology, Islamic Azad University Ayatollah Amoli Branch, Amol, Iran
3Assistant Professor, Department of Exercise Physiology, Islamic Azad University Ayatollah Amoli Branch, Amol, Iran
Abstract
Introduction: Cancer of the cervix is the second leading cause of cancer deaths in women worldwide and remains a leading cause of mortality among women of reproductive age in developing countries. Exercise is one of several lifestyle factors known to lower the risk of developing cancer. Moreover, the benefits of exercise continue after diagnosis. The aim of this study was to investigate the effect of taxol consume and endurance training on Cyclooxygenase2 and Prostaglandin in the Liver Tissue Mice C57 with cervical cancer.
Methodology: In this experimental study, 35 female C57 mice, eight weeks old, were randomly divided into 5 groups: control, cancer, complement, training, and training -supplementary with 7 mice in each group. The implantation of cancerous tumors was performed under the skin of the upper pelvis. The training group completed the endurance training protocol, which included 3 sessions per week, 50 minutes per session, at a speed of 14-18 m/s for six weeks. A dose of 60 mg/ kg/day, a pure extract of taxol was injected peritoneally Data were analyzed by t-test, One-way ANOVA and post hoc Bonferron's at the significant level P<0. 05.
Results: The results showed that the use of taxol and endurance exercises significantly reduced the levels of Cyclooxygenase2 in Liver tissues of C57 mice with cervical cancer (P = 0.000). Also, the use of taxol and endurance exercises significantly reduced the levels of Prostaglandin in Liver tissues of C57 mice with cervical cancer (P = 0.000).
Discussion: Based on the results, induction of cancerous tissue into mice increases the levels of cyclooxygenase-2 and prostaglandin, and endurance exercises along with taxol use may have beneficial effects on the agents involved in the cancer.
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