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The effect of six weeks aerobic training and taxol taking on interleukin 8 and Active inhibitor of plasminogen on mice with cervical cancer
Oral Presentation
Paper ID : 1611-11THCONF
Authors
11. MSc, Department of Exercise Physiology, Islamic Azad University Ayatollah Amoli Branch, Amol, Iran
2Associate Professor, Department of Exercise Physiology, Islamic Azad University Ayatollah Amoli Branch, Amol, Iran
3MSc, Department of Exercise Physiology, Islamic Azad University Ayatollah Amoli Branch, Amol, Iran
4Assistant Professor, Department of Exercise Physiology, Islamic Azad University Ayatollah Amoli Branch, Amol, Iran
Abstract
Introduction: There is increasingly convincing evidence that, especially within supervised programs, exercise mitigates many of the adverse toxicities common among cancer survivors and improves overall quality of life. The aim of this study was to investigate the effect of six weeks’ aerobic exercise and taxol consumption on interleukin 8 and active plasminogen activator in mice with cervical cancer.
Methodology: In this experimental study, 40 female C57 mice, eight weeks old, were randomly divided into 4 groups: cancer, cancer-taxol complement, cancer-training and cancer-training - taxol complement with 10 mice in each group. The implantation of cancerous tumors was performed under the skin of the upper pelvis. The training group completed the endurance training protocol, which included 3 sessions per week, 50 minutes per session, at a speed of 14-18 m/s for six weeks. A dose of 60 mg/ kg/day, a pure extract of taxol was injected peritoneally Data were analyzed by t-test, One-way ANOVA and post hoc Bonferron's at the significant level P<0.05.
Results: The results showed that there was a significant difference between mean values of interleukin-8 (P<0.05, F=12.25, F) and the active plasminogen inhibitor (P<0.05, P=0.10737, F) in four groups. A significance level of less than 0.05 in Tukey test for both variables also showed a significant difference between the "control" group and the complementary "exercise" group. Namely, six weeks of aerobic training, along with taxol, have a significant effect on the level of active plasminogen activator and interleukin-8 mice with cervical cancer.
Discussion: Considering the effect of training on these variables, this type of exercise can be used as a complementary therapeutic approach along with other therapies for cervical cancer.
Methodology: In this experimental study, 40 female C57 mice, eight weeks old, were randomly divided into 4 groups: cancer, cancer-taxol complement, cancer-training and cancer-training - taxol complement with 10 mice in each group. The implantation of cancerous tumors was performed under the skin of the upper pelvis. The training group completed the endurance training protocol, which included 3 sessions per week, 50 minutes per session, at a speed of 14-18 m/s for six weeks. A dose of 60 mg/ kg/day, a pure extract of taxol was injected peritoneally Data were analyzed by t-test, One-way ANOVA and post hoc Bonferron's at the significant level P<0.05.
Results: The results showed that there was a significant difference between mean values of interleukin-8 (P<0.05, F=12.25, F) and the active plasminogen inhibitor (P<0.05, P=0.10737, F) in four groups. A significance level of less than 0.05 in Tukey test for both variables also showed a significant difference between the "control" group and the complementary "exercise" group. Namely, six weeks of aerobic training, along with taxol, have a significant effect on the level of active plasminogen activator and interleukin-8 mice with cervical cancer.
Discussion: Considering the effect of training on these variables, this type of exercise can be used as a complementary therapeutic approach along with other therapies for cervical cancer.
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