The effect of Pilates training and massage therapy on plasma serum levels of IL-17 and IFNβ as pro-Inflammatory cytokines in patients with Multiple Sclerosis (MS)
Poster Presentation XML
Paper ID : 1631-11THCONF
1Assistant Professor
2Assistant Professor /zarbaijan Shahid Madani University
Introduction: Multiple Sclerosis (MS) is a chronic, debilitating nervous system disease, which damages the myelin of the central nervous system. The most common symptoms include fatigue, muscle spasms, tremors, double vision, lack of balance, and impaired walking. Cytokines play an important role in the pathogenesis of the disease and are considered an important objective for therapeutic in tervention. IL_17 has a direct relationship with MS. On the other hand, IFNβ plays a key role in MS improvement. This article aimed to study the effect of Pilates training and massage therapy on plasma serum levels of IL_17 and IFNβ as pro-inflammatory cytokines in patients with multiple sclerosis (MS).
Methodology: This is a clinical trial. A total of 36 women who had medical file in Multiple Sclerosis society of Tabriz, Iran –were enrolled as the sample. The degree of the disease was between 0 and 4/5. The average length of disease was 7±2 and the patients were between 30 and 40 years old. Selected and split in to 4 groups. Massage (n=9), pilates (n=9), pilates + massage (n=9), and a control (n=9). They were randomly assigned to Pilates and Massage groups. Exercise lasted for 8 weeks, 3 times a week. Each session lasted 40-60 minutes: 20-40 minutes for Pilates and 20-30 minutes for massage. Blood samples were taken before and after intervention and massage in order to measure the blood variables. Serum levels of IL_17 cytokine and IFNβ were measured using the ELISA. The data were analyzed by correlated t-test and ANOVA using spss20. The significance level was considered. (p<0/05)
Results: Showed that 8 weeks of Pilates and Massage caused a significant decline in IL_17 in Pilates, Massage, and Pilates + Massage groups. IFNβ also increase in Massage and Massage + Pilates groups. (P< 0/05).
Discussion: Since Pilates coupled with Massage reduced pro-inflammatory IL_17 cytokine and increase IFNβ of MS patients, it seems that Pilates and Massage can be used as a complementary treatment along with other drug therapies for preventing the progress of MS.