Resistance training and melatonin administration lowers some cardiovascular risk factors in overweight men: A randomized, double-blind, placebo-controlled trial
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Authors
1Department of Physical Education and Sport Sciences, Mahabad Branch, Islamic Azad University, Mahabad, Iran.
2Teacher
3Assistant Professor Department of physical education science and research branch islamic azad uinversity tehran iran
4Assistant Professor in Exercise Physiology
Abstract
Introduction: Considering the widespread obesity and overweight prevalence in Iran and around the world and its association with cardiovascular risk factors, the use of antioxidant supplements can be effective. It has been shown that melatonin is a classic antioxidant which has a potent anti-inflammatory effect and can reduce inflammation and lipid profiles. This investigation evaluated the effects of 8 weeks of increasing resistance training with melatonin supplementation on reactive protein C and lipid profiles in overweight men.
Methodology: In this clinical trial, 40 men with body mass index (BMI) between 25-30 (kg/m2) were randomly divided into four groups: training-supplement (N=10), training-placebo (N=10), supplement (N=10), and placebo (N=10). The training groups performed an progressive resistance training session, 3 sessions each week with 55-85% 1RM for 8 weeks. The treatment groups received the melatonin (5 mg/day, 2 hr before bedtime) for 2 months. The following parameters were measured: high-sensitivity C-reactive protein (hs-CRP), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C).
Results: The results showed that resistance training with melatonin consumption significantly decreased the hs-CRP, TG, LDL-C and significantly increased HDL-C in training–supplement (p=0.038, p=0.008, p=0.002, p=0.009), training-placebo (p=0.001, p=0.018, p=0.007, p=0.002) and supplement groups (p=0.038, p=0.008, p=0.002, p=0.009). However, TC significantly decreased in the training–supplement (p=0.012) and training-placebo (p=0.014), and remained unchanged in the other two groups (P>0.05).
Discussion: The results of this study showed that 8 weeks of progressive resistance training produced favorable changes in the hs-CRP level and lipid profiles. But the combination of resistance training and melatonin supplement have synergistic effects, and there was a significant difference compared to resistance training and placebo, which can prevent cardiovascular disease in overweight people.
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