The effect of high intensity interval training and herb supplement on heart IGF-1 concentration in male rats
Poster Presentation XML
Paper ID : 1767-11THCONF
1Azad University
2Islamic Azad University, Central branch
3Islamic Azad University, Central Branch
Introduction: The objective of the present study was to determine the effect of 10 weeks of high intensity interval training and flaxseed oil supplement on heart IGF-1 concentration in male rats.
Methodology: 20 adult male Wistar rats were randomly divided into saline, saline–training, supplementation, and supplementation–training groups. The training groups performed training (10 weeks, five sessions per week, 90–95% VO2 max) on a rodent treadmill. The supplementation groups also received flaxseed oil supplement (30 mg/kg). The rats were sacrificed five days after the last training session. The heart tissue was collected, and sent to the laboratory for evaluation.
Results: Two-way variance analysis on cardiac IGF-1 showed a significant difference between training groups and control groups (F=8.502, P=0.01). Training leads to a significant increase in IGF-1 concentration in the cardiac tissue. Further, IGF-1 concentration in supplementary groups was significantly more compared to saline (F=15.921, P=0.001). Furthermore, training and supplementary interaction showed a significant increase compared to the other groups (F=11.747, P=0.003).
Discussion: In general, it seems like the training type is effective on IGF-1 concentration. The results of studies indicate that intense training affects IGF-1 concentration and the results of the current research show that HIIT, just like any other intense training models, leads to an increase in IGF-1 concentration. Flax seed oil is abound with unsaturated fatty acids Omega-3 and Omega-6. These fatty acids are effective on gene expression of IGF pathway components, and IGF-1 increases in response to flax seed oil probably by this mechanism, albeit it requires further studies.