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Effect of an acute training by different intensities on CDNF levels in male rats
Poster Presentation
Paper ID : 1810-11THCONF
Authors
1lecturer
2Assistant Professor,Department of Physiology, Faculty of physical Education & Sport Science, University of Mazandaran
3Department of Physiology, Islamic Azad University, Sari Branch
Abstract
Introduction: The most prominent of Parkinson's disease is dopamine cell loss and reduced dopamine levels in the striatum. The neurotrophic factors cause effects of the cell survival, growth, differentiation, protection of the neural connections and also the neuroplasticity. The purpose of this research was to investigate the effect of acute running by various intensities on level of cerebral dopamine neurotrophic factor in striatum of male rats.
Methodology: Thirty two adult male rats After two weeks adaptation divided into four groups (control, low intensity training, moderate intensity training, high-intensity training). the training groups performed seven sessions to learn how do on treadmill. After that these groups did an acute training with difference intensities. the striatum immediately after training extracted. Then cerebral dopamine neurotrophic factor concentrations were measured by ELISA. After confirm the normality of data by using of Kolmogorov-Smirnov for comparison between groups, data was analyzed using one-way analysis of variance (ANOVA) and LSD post-hoc test.
Results: the results shows that acute training with low-intensity (P=0.46) and moderate-intensity (P=0.32) has no significantly effect on level of striatum cerebral dopamine neurotrophic factor, nonetheless difference in high intensity (P=0.021) of training was significant.
Discussion: We conclude that low and moderate intensities training do not increase levels of Cerebral dopamine neurotrophic factor in striatum rats, nevertheless these levels can increased due to high-intensity training. Therefore the pattern of high-intensity training can improve levels of Cerebral dopamine neurotrophic factor as one of the effective mechanisms to protect neurons and prevention of neural diseases like Parkinson’s disease.
Methodology: Thirty two adult male rats After two weeks adaptation divided into four groups (control, low intensity training, moderate intensity training, high-intensity training). the training groups performed seven sessions to learn how do on treadmill. After that these groups did an acute training with difference intensities. the striatum immediately after training extracted. Then cerebral dopamine neurotrophic factor concentrations were measured by ELISA. After confirm the normality of data by using of Kolmogorov-Smirnov for comparison between groups, data was analyzed using one-way analysis of variance (ANOVA) and LSD post-hoc test.
Results: the results shows that acute training with low-intensity (P=0.46) and moderate-intensity (P=0.32) has no significantly effect on level of striatum cerebral dopamine neurotrophic factor, nonetheless difference in high intensity (P=0.021) of training was significant.
Discussion: We conclude that low and moderate intensities training do not increase levels of Cerebral dopamine neurotrophic factor in striatum rats, nevertheless these levels can increased due to high-intensity training. Therefore the pattern of high-intensity training can improve levels of Cerebral dopamine neurotrophic factor as one of the effective mechanisms to protect neurons and prevention of neural diseases like Parkinson’s disease.
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