The effects of endurance exercise and methylphenidate consumption on prefrontal in ADHD rats
Poster Presentation XML
Paper ID : 1925-11THCONF
Psychology Faculty of Islamic Azad University, West Tehran Branch, Tehran, Iran
Introduction: The use of methylphenidate has recently been used to reduce the symptoms of hyperactivity in children ADHD. The aim of this study was to investigate The effects of endurance exercise and methylphenidate consumption on prefrontal in with Attention Deficit Hyperactivity Disorder (ADHD) rats
Methodology: A experimental research method was used. The subjects were 40 Wistar rats (mean and standard deviation of 181.78 ± 8.39 g) and aged 8-12 weeks. A 5-member group (mean and standard deviation of 182.6 ± 51.6 g) were randomly selected for sampling and blood sampling, and 35 rats (mean and standard deviation of 181.66 ± 8.09 g) to 5 Group 7 (control group and 4 groups of attention deficit hyperactivity disorder: methylphenidate use, endurance training, methylphenidate use and endurance training, without methylphenidate and no endurance training). 10 mg L-NAME for 8 weeks and 6 days per week for each rat was injected sub peritoneally for the attention deficit-hyperactivity disorder in rats. Angiotensin converting enzyme (ACE) and nitrite oxide (NO) were used to detect hypertension in rats after L-NAME injection. The open field test for over-active detection, and 5-band treadmill for endurance training of rats were used. The drug group received 2 mg of methylphenidate daily per kg of body weight orally. The rats ran for 28 days each day (5 days a week) for 28 days. The practice load for training groups included running at speeds of 2 to 8 m / min for 30 minutes. Descriptive statistics were used to determine mean, mean, standard deviation, drawing tables and charts. For normalization of the distribution of dependent variables from the Kolmogorov-Smirnov and the assumption of the equation of variances, the Levine test and the correlation t were used to examine the intra-group weight variations and one-way variance for intra-group variation.
Results: The Tukey's post hoc results showed that the increased lipid peroxidation and protein damage ADHD group was higher lower than all groups (P<0.001). There was no significant difference between ADHD + endurance exercises with ADHD + methylphenidate group; Also ADHD + methylphenidate + endurance exercises.
Discussion: It seems that methylphenidate has a negative effect on the forehead cortex and it is suggested that other studies be conducted to rely on the results of the study.